- 1 What is Metformin?
- 2 Interaction of Metformin with other medicines
- 3 Metformin during pregnancy and lactation
- 4 Metformin dosage
- 5 Side effects of Metformin
- 6 Storage of metformin
- 7 FAQ’s:
- 8 References:
Diabetes management is crucial to keep your blood sugar levels in control. High blood sugar levels can lead to serious health issues including liver and kidney issues and cardiac arrest. Diabetes management mainly includes lifestyle change, diet control, and work out. Along with these, medication is also very important to control your diabetes. The ‘US Food and Drug Administration’ has approved Metformin as an approved drug to treat diabetes.
What is Metformin?
Metformin or metformin hydrochloride is a prescribed oral drug. It is the generic name of Glucophage. It helps in controlling blood sugar levels in adults with type-2 diabetes mellitus. You can take it with other medications or insulin to keep your blood sugar levels in the normal range. This medicine is not for people with diabetes type-1.
How do Metformin works?
Metformin helps in lowering your blood glucose levels. It performs multiple functions in your body to prevent spikes in blood glucose levels and also reduces the amount of glucose (sugar) made by your liver. It decreases the amount of glucose that your body absorbs and increases the effect of insulin on your body.
Forms of Metformin
Metformin oral tablets are available in two forms. One is the immediate-release metformin and the other is extended-release metformin. Both forms of metformin contain the same active ingredients. However, there are different ways to take both metformin.
- Metformin Immediate Release: This form of metformin is available in 500 mg tablet. You need to take this medicine twice a day with food. Also you can find 850 mg immediate-release metformin hydrochloride tablets. You need to take it once a day. The maximum dose of immediate-release metformin is 2000 mg per day. It can be in divided dosage. Immediate-release metformin is suitable for both adults and children.
- Metformin Extended Release: It is the extended version of metformin to treat diabetes. The maximum dose of extended-release metformin is 2000 mg. However, a person with diabetes needs to take it once a day. It is ideally only for adults with type-2 diabetes. A person with diabetes type-2 should strictly take this medicine under the advice of a doctor because it has some side effects. However, its effect lasts longer than regular metformin.
Interaction of Metformin with other medicines
One dark side of Metformin hcl drug is that it can easily interact with some medicines. The drug interaction can change its working and affect the effectiveness. This also increases the risks of serious side effects. Therefore, it is recommended to share with your doctor the details of all the medicines that you take. Some of the drugs that easily interact with Metformin are:
- Antibiotics: There are some antibiotics like rifampin that prevent metformin to perform its functions.
- Blood Pressure drugs: Taking diuretics can increase your blood sugar levels. Therefore taking these drugs with metformin will not give you effective results.
- Diabetes drugs: Insulin or some insulin-releasing medicines when taken with metformin reduces your blood sugar levels. It can cause hypoglycemia.
- Thyroid drugs: There are few thyroid drugs like desiccated thyroid, levothyroxine, liothyronine, and liotrix which make metformin less effective.
- Topiramate: This drug treats seizure and nerve pain. Taking topiramate with metformin increases the risk of lactic acidosis. Do not use these medicines together.
- Cholesterol drugs: The cholesterol controlling drug, Niacin increases your blood sugar levels. Metformin and cholesterol drugs do not work together.
- Glaucoma drugs: Taking glaucoma treating drugs with metformin increases the risk of lactic acidosis.
- Hormone drugs: Metformin with certain other drugs are less effective in reducing your blood sugar levels. Avoid metformin with hormone drugs like estrogen and corticosteroids. Metformin also promotes ovulation. It causes changes in the menstrual cycle and hence increases the chance of getting pregnant.
Apart from these, there are some more drugs that easily interact with metformin and make it less effective. So, you should note the other medicines that you are taking with metformin.
Metformin during pregnancy and lactation
Women can take metformin during pregnancy with diabetes. Pregnant women need to take consultation with a gynecologist before taking metformin. Generally, pregnant women take insulin to control their increased blood sugar levels. Metformin can easily enter breast milk. It can cause side effects to the breastfeeding child. Thus, metformin should be avoided during lactation or breastfeeding.
It is important to take metformin exactly in the dose as the doctor prescribes you. Do not chew or crush the metformin tablets. You need to swallow it as a whole. The dose of metformin prescribed to the patients depends upon several factors. These include:
- the form of metformin you take
- severity of your diabetes
- your age
- your medical conditions
Initially, your doctor may start with a low dose. Over time the doctor adjusts your dosage according to your blood sugar levels. However, you need to ensure to take the dosage that your doctor prescribes. The doctor prescribes you the dosage that suits your health condition.
Dosage for type-2 diabetes
Dosage for type-2 diabetes for adults is:
- Immediate-release tablets are available in 500 mg and 850 mg. The doctor suggests taking these medicines twice per day and once per day respectively. Patients need to take the immediate-release metformin tablets with meals. Your doctor can increase your dose up to a total of 2,000 mg per day in divided doses.
- Extended-release tablets are available in 500 mg. You need to take it once a day with your evening meal. A doctor can increase your dosage of metformin hydrochloride 500 mg every week on the basis of your blood glucose levels. The maximum dose of extended-release tablet is 2,000 mg per day. You can take the extended-release tablet once a day. Still, if your doctor realizes the need to increase the dosage, your doctor will divide the dose into two.
People older than 80 years of age should not take metformin especially if they have kidney problems. Older people also have a higher risk of lactic acidosis.
Overdose of metformin
Overdose of metformin may lead to some side effects including hypoglycemia and lactic acidosis. In case you miss your metformin dose, you need to take the medicine as soon as you can. Do not try to add up your missed dose with the next dose. It can cause low blood sugar. If you miss the dose, take the next dose at the correct time.
It is very important to take metformin in the prescribed doses only. Your doctor considers your blood sugar level, health condition and age to decide the suitable dose of metformin for you. Exceeding the prescribed dose without consultation can give several side effects of this drug.
Side effects of Metformin
There can be mild or serious side effects of metformin. If you experience any below mentioned are the mild side effects nevertheless, you need to immediately stop metformin and inform your doctor.
- Stomach upset
- Metallic taste in the mouth
The serious side effects of metformin Lactic Acidosis and Hypoglycemia. These are rare but can be fatal for the person with diabetes, who is taking metformin.
Lactic Acidosis: A serious side effect of metformin
Lactic acidosis is a medical condition caused by the build-up of lactic acid in your body. It is a kind of metabolic acidosis that results due to an overproduction or underutilization of lactic acid. It mainly happens when there is no enough oxygen in your muscles to break down glucose and glycogen. The build-up of lactic acid causes an imbalance in the pH level of your body.
Patients who are at the risk of Lactic Acidosis:
Lactic Acidosis is more likely to occur in patients who have kidney or liver issues and serious infections. Those who have experienced recent congestive heart failure, heart attack, and stroke are also at the risk of developing lactic acidosis. Heavy alcohol use, a severe loss of body fluids (dehydration), or X-ray or scanning procedures that require an injectable iodinated contrast drug also increases the chances of Lactic Acidosis.
Symptoms of lactic acidosis
The common symptoms of lactic acidosis are as follows:
- Breathing troubles
- Severe Drowsiness
- Slow or irregular heartbeat
- Unusual muscle pain
- Cold arms and legs
- Unexplained stomach and intestinal issues
- Feeling weak or tired
Prevention of Lactic Acidosis
If you notice any of the above-mentioned symptoms, stop taking metformin and call your doctor. There are certain metformin interactions that can result in lactic acidosis. Thus, you need to inform your doctor about all the other prescription medicines, vitamin, herbal and over-the-counter medicines that you are taking along with metformin.
Hypoglycemia: A common but serious side effect
Metformin usually does not cause low blood sugar levels. If you still experience low blood sugar levels, you need to talk to your doctor. It can be due to the interaction of metformin with some other prescribed medicine. The doctor will either change your other medicines for diabetes or lower their dose.
Symptoms of Hypoglycemia
Some of the visible symptoms of hypoglycemia are:
- Tingling of hands and feet
- Sudden sweating
- Faster heartbeat
- Blurred vision
You are also supposed to monitor your blood glucose levels for few days when you start taking metformin. It will help you and your doctor to know if metformin is working effectively on your body or not.
Treatment of Hypoglycemia
When you don’t know if metformin can lower your blood sugar levels or not, it is good to carry some glucose tablets. It will immediately raise your blood glucose. You can also have sugar, candy, honey, or fruit juice on experiencing the symptoms of low blood sugar levels. It will help you to avoid the consequences of hypoglycemia. After that, you can immediately inform your doctor about the reaction. The doctor will change the dosage of metformin or prescribe you the alternate medicine.
Metformin can easily interact with the other medicines. Also, there are some health conditions in which metformin is less effective in lowering blood glucose levels. Hence, it is recommended to avoid taking metformin without a prescription. It can cause several mild or serious side effects including lactic acidosis and hypoglycemia that can affect your health for the worse.
Storage of metformin
Metformin is best stored at a temperature between 68°F and 77°F. The temperature between 59°F and 86°F is also suitable for its storage. Keep this drug away from light and high temperatures. Also, keep it away from moist and damped areas. This can spoil the drug. You can also check the label of the pack of this drug to know the storage details.
Diabetes increases the risk of severe health conditions. Hence, it is important to keep your diabetes in control. The most effective methods for diabetes management include diet control, lifestyle change, and medications. Metformin is the most effective and affordable drug option for controlling diabetes. Take metformin in the prescribed dosage to work effectively to manage your blood glucose levels.
Can I test my blood sugar levels with a glucometer while taking Metformin?
How long can I take metformin?
Once you develop diabetes type-2, you will have to live with it for the rest of your life. If you have diabetes type-2, you are advised to take metformin throughout your life. Your blood sugar levels will remain in control as long as you take your metformin.
Is it safe to drink alcohol while taking Metformin?
It is advised to refrain from drinking alcohol while taking metformin. Alcohol can lead to low blood sugar levels. Hence, drinking alcohol with Metformin can affect the control of blood sugar levels.
Can anyone who is suffering from diabetes type-2 take Metformin?
It is suggested to take Metformin only on the advice of your healthcare provider or general physician. One side effect of Metformin is lactic acidosis. Therefore, people with diabetes suffering from kidney, liver, and heart problems are advised to avoid metformin.
Is Metformin safe?
Metformin is a completely safe and effective medication for treating diabetes. This drug is available worldwide at affordable rates. You can buy it from any online or physical medical stores.