Gliclazide + Metformin Tablets to Control Your Blood Sugar Levels

Last updated on July 18th, 2023

Gliclazide directly stimulates the secretion of insulin in your body. It helps in controlling your blood sugar spikes. Many doctors recommend a combination of Gliclazide and Metformin to have the dual action in managing blood sugar levels. It is essential to take the diabetes medications after proper consultation with a doctor. It will prevent the side effects. Taking Gliclazide-Metformin tablets in the wrong way can potentially result in hypoglycemia. Diabetes patients should also check the drug interaction to avoid side effects.

With the increasing number of diabetes cases, several diabetes medications are now available in the market. Such medicines help diabetes patients to keep their blood sugar levels normal and help them live a healthy life. Metformin Uses is One of the safest diabetes medicines. Many times, Metformin is taken in combination with other diabetes medicines to manage your diabetes effectively. Gliclazide-Metformin is one such medicine that is popular these days.

gliclazide + metformin

Gliclazide + Metformin

Gliclazide and Metformin are oral medicines for diabetes management. The combination of Gliclazide and Metformin works better with diet and exercise to improve blood glucose levels. It treats diabetes type-2, and patients with diabetes type-1 may get its benefit in managing diabetes. Though both medications lower blood glucose levels, they work differently. Gliclazide increases Insulin production in your body, while Metformin reduces the amount of glucose the liver produces.

Also Read: Foods to Avoid While Taking Metformin

Side Effects of Gliclazide + Metformin

Since there are so many anti-diabetes medicines, you should not start taking the medications without a prescription. It will lead to several side effects. The same happens with Gliclazide-Metformin Tablets. Taking this medication can cause some side effects in diabetes patients. In such a case, you need to stop taking Gliclazide-Metformin tablets immediately.

Some side effects of Gliclazide-Metformin tablets are:

  • Upset stomach
  • Nausea
  • Hypoglycemia
  • Diarrhea
  • Headache
  • Stuffy nose
  • Sore throat

Some diabetes patients experience rash, itching, bruising, weakness, fever, or shivering. These are mild symptoms and often go away without medication.

Also Read: Galvus met 50/500 mg tablet uses 

Ways to Cope Up With the Mild Side-Effects


Almost all medications have some or the other side effects. But one can always deal with mild side effects with the help of some basic remedies.

Some of the ways to cope up with the mild side effects are:

  • For stomach upset or indigestion, take a rest and relax. You need to eat and drink slowly. Instead of having a big meal, small and frequent meals make you feel better. Placing a hot water bag also helps in treating your upset stomach and indigestion.
  • If you feel nausea, stick to the oil-free meals. Avoid eating rich and spicy meals. Also, take your Gliclazide-Metformin Tablets with the meals.
  • Some people taking Gliclazide-Metformin may face the problem of constipation. They should eat fiber-rich food, include more fruits and vegetables in the diet, and drink lots of water. Simple exercises like walking, jogging, and yoga can also give them relief from constipation.
  • Vomiting and diarrhea are the other mild side effects of taking Gliclazide-Metformin tablets.  If you feel like vomiting or suffering from severe loose motions, drink plenty of water to avoid dehydration. Do not take any medicine to treat vomiting or diarrhea without consultation. It can affect your blood sugar levels and make you sick more.

However, you may need to contact the doctor if these side effects continue for a longer time or become bothersome.

Also Read: Metformin Side Effects: Common, Severe and Long Term

Serious Side-Effects of Gliclazide-Metformin


Other than the mild side effects, Gilclazide-Metformin can have certain serious side effects as well, such as bleeding, swelling, low blood sugar, metabolic complications, and cardiovascular problems, among others.

The serious side effects of Gliclazide-Metformin can be fatal for your life if you do not get immediate help from the doctor. You need to call the doctor straight away if you see the following symptoms after taking Gliclazide-Metformin:

  • Prolonged bleeding, paleness on your face and body, sore throat, or fever can be the symptoms of a blood disorder.
  • Yellowing of the sclera of your eyes or yellow skin can be a sign of a liver problem.
  • Sudden swelling of the eyelids, redness, skin rashes, itching, hives, and breathing difficulty are the problems that are signs of a skin disorder called Angioedema.
  • Temporary loss of vision as a result of low blood sugar levels.

Low Blood Sugar Levels Due to Gliclazide-Metformin

The combined action of Gliclazide and Metformin can sometimes cause Hypoglycemia. There can be a sudden drop in your blood sugar level. Sometimes, the patients are unable to understand that their blood sugar is getting low. The early signs and symptoms of low blood sugar levels are:

  • Sweating
  • Confusion
  • Problem in Concentrating
  • Dizziness
  • Feeling Hungry
  • Trembling

Diabetes patients may experience hypoglycemia while asleep. It can make them feel sweaty and tired. They may also feel confused after waking up.

Causes of Hypoglycemia: Some causes of Hypoglycemia when you are taking Gliclazide-Metformin tablets are:

  • Taking too much of Gliclazide
  • Irregular meals
  • Pre-existing liver and kidney problems while you start taking Gliclazide-Metformin Tablets
  • Drink alcohol, especially on an empty stomach
  • Taking some other medicine that can interfere with the working of Gliclazide

Take all the precautions to take tablets to avoid Hypoglycemia. Carry the fast-acting carbohydrates along with you. It will help you to maintain your blood sugar levels instantly if you experience the symptoms of low blood sugar levels.

Also Read: Tenglyn M 500 Tablet Uses, Side Effects and Dosage

Metabolic Complication

Metabolic complication is one of the serious side-effects of Gliclazide-Metformin Tablet. However, lactic acidosis is rare.  The metabolic complication occurs due to the accumulation of Metformin while treating high blood sugar levels with Gliclazide-Metformin tablets. The increase in the blood lactate levels shows that you have developed lactic acidosis. Thus, your Metformin plasma levels are more than 5 μg/mL. Though, the chances of developing lactic acidosis in diabetes patients taking Metformin are low.

Increase in Risk of Cardiovascular Mortality

The administration of the Gliclazide-Metformin or some other diabetes control medicines can increase cardiovascular mortality. The risk of developing cardiovascular mortality is higher in diabetes patients taking medications to control diabetes than in patients following a diabetic diet and exercise to manage blood sugar levels. Therefore, you should inform your doctor of heart-related or cardiovascular problems. It will help you to maintain your cardiovascular health and avoid complications.

Also Read: Diet Plan For Diabetes Patient India

Caution With the Medicines While Taking Gliclazide + Metformin

Most of the medicines could interfere with the way Gliclazide + Metformin work. Here is a list of some medicines that you should inform your doctor about while taking Gliclazide + Metformin:

  • Steroid tablets
  • Painkillers
  • Medicines for treating asthma
  • Medications for treating heart problems
  • Medicine to treat bacterial and fungus infection
  • Medicine for boosting male and female hormones
  • Other diabetes medicines
  • Medications for thinning your blood

Avoid Mixing Herbal Medications and Supplements with Gliclazide-Metformin Tablets

The working of the Gliclazide-Metformin tablet can interfere not only with allopathic medications but with herbal medications as well. Therefore, do not mix the herbal medicines and supplements with medicine. It may change how your body processes Gliclazide. Even if you are taking Vitamins or other health supplements, you should avoid Gliclazide-Metformin.

Drug Interaction of Glipizide and Metformin

Some drugs cause hyperglycemia and may lead to the loss of blood sugar control. Such drugs include corticosteroids, oral contraceptives, phenothiazines, thyroid products, thiazides, and other diuretics, estrogens, nicotinic acid, phenytoin, sympathomimetics, calcium channel blocking drugs, and isoniazid. It can cause a severe drop in blood sugar levels if you give any of these drugs to the patients taking medicine. Sometimes, it leads to loss of consciousness or death. Therefore, consult your doctor to avoid drug interaction.

Also Read: Janumet tablet side effects

Dosage of Gliclazide and Metformin

The dosage of Gliclazide-Metformin for adults with diabetes type-2 are:

  • Patients with inadequate glycemic control on diet and exercise should start with 2.5 mg-250 mg tablets orally once a day.
  • Diabetes patients who have Fasting Blood Glucose levels between 280 and 320 mg/dL can take the initial dose of 2.5-500 mg twice a day.
  • The doctors recommend the initial dose of 2.5 mg-500 mg or 5 mg- 500 mg twice a day to the patients with inadequate Glycemic control on Glipizide and Metformin.

Points to Remember for the Dosage of Gliclazide-Metformin

There are few things to remember regarding the Gliclazide and Metformin dosage. It will help you to maintain your blood sugar levels healthily:

  • Do not exceed the daily dose of gliclazide and metformin.
  • Monitor the signs and symptoms of hypoglycemia.
  • The initial doses should be conservative to prevent hypoglycemia. It can be due to gliclazide and gastrointestinal side effects because of Metformin.
  • Take Gliclazide-Metformin tablets with meals.

Ensure to take Gliclazide-Metformin tablets in adjunct to diabetic diet and exercise to improve glycemic control in patients with type-2.

Overdose: If you miss a dose, do not try to overdose Gliclazide-Metformin. It can lead to low blood sugar levels. Symptoms of overdose include headache, shakiness, an increase in hunger, and sweating. If you mistakenly overdose on the medication, consult your doctor immediately to prevent the consequences of hypoglycemia.

Also Read: Best Rated Glucometer in India

Gliclazide-Metformin in Pregnancy and Breastfeeding

Women having diabetes at the time of conceiving or develop gestational diabetes need to take diabetes control medications. It helps them to keep their blood sugar levels in control and avoid the related complications in their pregnancy. However, they should not start with any diabetes control medication without a prescription. Gliclazide-Metformin is one of the anti-diabetes medicine that is not suitable for pregnant women and lactating mothers. It can cause harm to the unborn baby. Gliclazide may also pass through the breast milk to the baby.

Storage of Gliclazide-Metformin Tablets

The storage of Gliclazide-Metformin tablets plays a critical role in giving the best results in managing diabetes. Store Gliclazide-Metformin tablets at room temperature between 59 and 86 degrees F. Keep the pack of this medicine away from direct sunlight, heat, and moisture. Make sure to keep it away from the reach of the children. If you are traveling with medicine keep it in the original packing or store it in the air-tight container.

Also Read: Hba1c test normal range


What are the specific conditions when the sugar patients should not take Gliclazide-Metformin tablet?

Sugar patients need to consult with the doctor to take Gliclazide-Metformin to manage their diabetes. Gliclazide-Metformin tablets are not for all sugar patients. If you are allergic to any of the ingredients of this medicine, you should not take this medicine. Sugar patients with kidney problems and underlying metabolic acidosis should strictly avoid Gliclazide-Metformin to avoid the severe side effects.

Can I take Gliclazide at night?

When you start with Gliclazide, you should consider the time-action profile of Gliclazide with the information about the diet and the activity of the patient. Gliclazide has an onset of 1-2 hours while its peak is of 4-6 hours. Therefore, Gliclazide keeps your blood sugar levels lower up to the evening meal if you take Gliclazide with breakfast. Similarly, it keeps your blood sugar levels in control pre-bed and during the night if you take it with the evening meal.

Is it safe to take painkillers with Gliclazide?

It is vital to take suggestions from your doctor before taking any medicine while you take Gliclazide. Like the other medicines for diabetes, Gliclazide also interacts with some drugs. Thus, it can give you some side effects or complications to your health. Paracetamol is, however, safe to take as a painkiller with Gliclazide. However, you should avoid taking Aspirin or ibuprofen. It can interact with Gliclazide and leads to low blood sugar levels.

How long do I need to take Gliclazide?

Once you develop diabetes, you have to live with it for a lifetime. Therefore, the treatment of diabetes also goes for lifestyle. If you start taking Gliclazide, you should not stop it without consultation. Discuss with your doctor first before stopping Gliclazide.

How do Gliclazide works?

Gliclazide belongs to the class of medicine Sulfonylurea that helps increase the production of insulin in your body. It is beneficial for diabetes patients whose bodies do not produce enough insulin to control their blood sugar levels.

Last Updated on by Dr. Damanjit Duggal 


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