Dibeta 500 MG SR Tablet: Uses, Side Effects, Composition, Substitutes, Dosage

Dibeta SR Tablet reduces the high blood glucose level. Sugar levels rise because of improper insulin production or its usage in the body. This condition is also known as type 2 diabetes mellitus. According to WebMD, this medication reduces the body’s sugar. Also, Dibeta increases the body’s response to insulin. Combinations of Dibeta with sulphonylureas are also available. The combination medicine reduces the total cholesterol levels in the blood. Also, it might enhance the risk of low blood glucose levels (hypoglycemia).

Dosage and Directions for Use of Dibeta SR Tablet

The advisable dose of Dibeta SR for adults is:

  • initial dose of 850 mg once a day
  • 500 mg two times a day with food
  • maximum dose is 2550 mg per day

The normal dose for children is:

  • initial dose of 500 mg two times a day
  • maximum dose is 2000 mg in children 10-16 years of age.

A person can take a Dibeta SR Tablet with food. Take the medicine with meals twice or thrice a day. Consume this medicine in the evening. Dibeta SR is not known to cause addiction. This medicine is to be used for extended periods. A person must use the Dibeta SR tablet per the doctor’s instructions.

To reduce the likelihood of side effects, a person can use the ER form of Dibeta. The ER form helps maintain a steady level of active drugs in the body for a longer period of time. Avoid chewing or crushing the tablet. Also, if a person stops taking this medicine, they may experience withdrawal signs like low sugar levels.

The dose and frequency of Dibeta SR depend upon some factors. These are:

  • patient’s age
  • overall health
  • liver and kidney health
  • medicines suggested by doctor
  • other medications or herbal supplements being used


  • Store Dibeta SR Tablet at room temperature of 20°–25° C.
  • Keep the medication away from moisture, heat, and light.
  • Keep it away from the reach of children and pets.



  • Strength: 500 mg, 850 mg, and 1000 mg

Extended-Release Tablets

  • Strength: 500 mg and 750 mg

Sustained-Release Tablets

  • Strength: 500 mg, 750 mg, and 1000 mg

Oral solution

  • Strength: 500 mg/5 ml

Missed Dose

Take the missed dose with food as soon as a person remembers it. Avoid consuming double doses to make up for a missed dose.


The most effective means to remove excessive amounts of lactate and Dibeta SR is hemodialysis. According to the National Institutes of Health, Hemodialysis purifies the blood and removes damaging substances from the body.

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Signs of Dibeta SR overdose

Signs of Dibeta SR overdose

If a person consumes excessive Dibeta SR, it may cause dangerous levels of medication in the body. In such cases, signs can include:

  • feeling of uneasiness
  • irregular heart rate, as stated by the AHA Journals
  • breathing issues
  • dizziness
  • severe tiredness
  • stomach pain
  • low blood pressure
  • muscle pain
  • lowered body temperature
  • vomiting
  • accumulation of lactate in the body

In case of an overdose of Dibeta SR Tablet, call a poison control center instantly.

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Before a person uses Dibeta SR, inform the doctor if he or she has conditions such as:

  • dehydration
  • irregular working of liver and kidney
  • prior exposure to surgery
  • alcoholism
  • heart failure (as per the NIH)
  • high ketone acids in the blood (diabetic ketoacidosis)
  • high acid level in the body (long-term metabolic acidosis)
  • severe infection
  • heart attack or stroke

Dibeta SR Side-effects

Dibeta SR Side-effects

According to Mayo Clinic, the following side effects might usually occur while using Dibeta. These are:

  • headache
  • flatulence
  • indigestion
  • loose stools
  • nausea, vomiting
  • stomach pain
  • taste disturbance
  • weakness
  • loss of appetite

Rarely, Dibeta SR may result in following side-effects:

  • hives
  • severe irritation of the skin (pruritis)

Read More: Januvia 100 mg – Uses, Side Effects and Dosage


Alcohol Intake

Excessive alcohol intake might cause lactate accumulation in the body. This is known as lactic acidosis. Thus, a person must not consume alcohol while taking Dibeta SR.

Elderly Patients

Proper monitoring of kidney work is essential in elderly patients. Do not give Dibeta SR to elderly patients.

Serious Conditions of Vomiting, Diarrhea, or Fever

Patients with serious conditions of vomiting, diarrhoea, or fever may suffer from dehydration. They might experience a severe loss of water in the body. Stop using the Dibeta tablet for a shorter time. Also, consult with a doctor about this.

Iodinated Contrast Agents

The use of IV iodinated contrast agents might increase lactate accumulation inside the body. This reduces kidney working. Stop the use of Dibeta SR before or at the time of treatment with these agents for 48 hours. Resume the use of Dibeta tablet if kidney working becomes stable.


Patients at the time of surgery under anaesthesia have a high risk while on Dibeta SR. Stop using the Dibeta tablet at the time of surgery for a minimum of 48 hours. Resume its use after the renewal of oral nutrition or if the kidney function becomes stable.

Heart Failure

Patients with heart problems are at high risk while on Dibeta SR. Such patients have an increased risk of low oxygen levels in the blood and abnormal kidney functioning. Low oxygen levels in the blood are known as hypoxemia. In patients with chronic heart failure, good monitoring of the heart and kidney functioning is essential. The use of this medicine is not safe in patients with unstable heart failure.

Read More: Pioglitazone Tablet – Uses, Side Effects and Dosage

Interactions with Dibeta SR

Interactions with Dibeta SR

When 2 or more drugs are given simultaneously, it might modify how the drugs work and increase the risk of side effects. In medical terms, this is known as Drug Interaction.

Other medications

Medications that interact with Dibeta SR may include:

  • thyroid products
  • birth control pills
  • estrogens
  • corticosteroids
  • phenothiazines
  • phenytoin
  • nicotinic acid
  • drugs for treating nerve disorders, seizures
  • medications for vitamin B deficiency.

In combination with these medicines, Dibeta SR can cause loss of blood sugar control. Proper monitoring of glucose levels is necessary in such patients.

Multidrug and Toxin Extrusion Inhibitors

Dibeta SR interacts with multidrug as well as toxin extrusion inhibitors. These include:

  • Ranolazine
  • Vandetanib
  • Dolutegravir
  • Isavuconazole
  • Trimethoprim
  • Cimetidine
  • Medicines for treating bacterial, viral, fungal infections, chest pain, ulcer, cancer.

The use of Dibeta SR with multidrug and toxin extrusion inhibitors enhances the level of Dibeta SR in the body. Also, the medicine might increase the risk of lactate accumulation in the body. Dose adjustment is essential while using these drugs in combination.

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Calcium Channel Blockers

Dibeta SR may interact with Calcium Channel Blockers. These drugs are nifedipine (to treat high blood pressure and chest pain). Dibeta SR, in combination with Nifedipine, increases the level of Dibeta SR in the blood.


Dibeta SR can interact with diuretics such as furosemide. This drug treats fluid accumulation in patients experiencing:

  • heart failure
  • kidney disorder
  • high blood pressure.

The use of furosemide with Dibeta SR enhances the level of medicine in the blood. Proper monitoring of the kidneys is necessary to adjust the dose of Dibeta. Also, a blood sugar level test is needed.

Blood pressure lowering agents

Special instructions must be followed while consuming the Dibeta SR tablet and medicines. Medicines may include thiazides, diuretics, calcium channel blockers, or sympathomimetics. These medicines treat blood pressure. The combination of Dibeta SR with thiazides, diuretics, sympathomimetics or calcium channel blockers may cause loss of blood glucose control. Observe these patients closely for low blood glucose levels.

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Organic Cationic Transporter Inducers-1

Doctor’s guidelines might require to be followed while using Dibeta SR tablet. These can be given with inducers of organic cationic transporter-1 (rifampicin). These medicines treat bacterial infections. Combination with Dibeta SR with organic cation transporter-1 inducer might enhance the absorption in stomach and intestine. Also, the combination may modify the efficacy of Dibeta SR. A suitable dosage adjustment is necessary while taking both drugs.

Non-Steroidal Anti-Inflammatory medicines

Dibeta SR interacts with NSAIDs. These medicines may include:

  • selective cyclooxygenase-2 inhibitors
  • angiotensin II receptor blockers
  • angiotensin-converting enzyme inhibitors

These medicines treat pain, fever, inflammation and high blood pressure. Use of Dibeta SR with these medicines may have an effect on the kidney functioning. And, this further gives rise to the risk of lactate accumulation in the body. Close kidney monitoring is essential while using these medications with Dibeta SR.

Organic Cationic Transporter Inhibitors-1 and 2

Special instructions must be followed while using this medicine along with:

  • inhibitors of organic cationic transporter-1
  • organic cationic transporter- 2 (crizotinib, olaparib)

These medications are helpful for treating cancer. When Dibeta SR is given with crizotinib, olaparib may modify the efficacy and remove Dibeta SR from the kidney. Suitable dose adjustment is essential while taking both medicines.

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Carbonic Anhydrase Inhibitors

Dibeta SR interacts with Carbonic Anhydrase Inhibitors. These medicines may include topiramate, zonisamide, acetazolamide, and dichlorphenamide. They help to treat damaged optic nerve (glaucoma). The use of this medicine with carbonic anhydrase inhibitors might increase the risk of lactate build-up in the body. Frequent monitoring is vital in such patients.

Expired Medication

Using a single dose of expired Dibeta SR is doubtful to bring about a side effect. Yet, discussing with a doctor or pharmacist is vital if a person feels unwell or ill. An expired drug may become unproductive in treating the prescribed conditions. To be on the safe side, it is vital not to use an expired drug.

Safe Disposal of Medication

  • If there are disposal guidelines on the package, it is important to follow the instructions.
  • If precisely indicated on the package that it must be flushed when no longer needed, carry out the mandatory step.

Substitutes for Dibeta SR 500 Tablet

Substitutes for Dibeta SR 500 Tablet
Medicine Brand Name Manufacturer
Mefomin 500 SR Tablet Macleods Pharmaceuticals Pvt Ltd
Glycomet 500 SR Tablet USV Ltd
Glyciphage SR 500mg Tablet Franco-Indian Pharmaceuticals Pvt Ltd
Gluconorm SR 500mg Tablet Lupin Ltd
Metsmall 500 Tablet SR Dr Reddy’s Laboratories Ltd
Riomet OD 500mg Tablet SR Sun Pharmaceutical Industries Ltd
Bigomet SR 500 Tablet Aristo Pharmaceuticals Pvt Ltd
Xmet-SR Tablet Glenmark Pharmaceuticals Ltd
Walaphage -SR 500 Tablet Wallace Pharmaceuticals Pvt Ltd
Metadoze-IPR 500 Tablet SR Biocon
Metlong 500 Tablet SR Panacea Biotec Ltd
Sugamet SR 500 Tablet Zydus Cadila
Metaday 500 Tablet SR Wockhardt Ltd
Zomet SR Tablet Intas Pharmaceuticals Ltd
Recemin 500mg Tablet SR Bharti Life Sciences

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FAQ’s (Frequently Asked Questions)

Is it safe to give Dibeta SR during breast-feeding?

It is unknown whether Dibeta SR passes into breast milk. Thus, is not suggested for use during breastfeeding.

Is it safe to use Dibeta SR during pregnancy?

Use of Dibeta SR tablet is not safe during pregnancy. It might affect the foetus.

Is Dibeta SR an addictive medicine?

No, it is not a habit-forming medicine.

Can I take alcohol with Dibeta SR?

Avoid the intake of alcohol while treatment with Dibeta SR. This interaction results in some severe side effects like drowsiness or reduced blood glucose levels.

Last Updated on by Dr. Damanjit Duggal 


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