इंसुलिन रेजिस्टेंस के कई कारण हो सकते हैं, जैसे खराब लाइफस्टाइल, ज्यादा वजन, फैमिली मेडिकल हिस्ट्री, अनहेल्दी भोजन, हाई-ब्लडप्रेशर, हाई-ट्राईग्लिसराइड, लो-एचडीएल, हाई-कार्ब डाइट, उम्र, नींद की समस्याएं, आदि।
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